Research Interest: Anterior and Posterior Spine Surgery; Cranio-Cervical Junction Surgery, Pain Therapy; Minimally Invasive and Endoscopic Spine Surgery;  Spinal Neurooncology, Application of Hemocomponents in Spine Surgery;  Spine Trauma, Neurotraumatology, Biomolecular Research for Bone Augmentation.

Research Interest: Cerebral vascular disease including stroke; 2. Stem cell transplantation including regenerative translational science in neurology; 3. Brain-heart connection including Afib and migraine with stroke; 4. Vascular dementia; 5. Stroke prevention and acute management; 6. Neuro-critical care and emerging neurohospitalist service. (Path)physiology of vascular disease and modification; 8. Neuro imaging and rare neurological disorders

Research Interest: On the Elucidating of Mechanisms of Cell Death, Gliosis, Inflammation   and   Neurogenesis   Via   Several   Models   of   Brain   Damage and   How Inflammatory Mediators Connect The Brain With The Periphery. To Date, My Research Has Mainly Been  Dedicated  Towards  The  Development  of  Novel  Therapeutics  to Repair  The  Brain  After Damage.

Dr. Huanhuan Liu is Associate Professor of Psycholinguistics at the Research Center of Brain and Cognitive Neuroscience of Liaoning Normal University. She earned her PhD from the Department of Psychology at Beijing Normal University. Her research interests include bilingual switching and language learning. She conducted psycholinguistics and neurolinguistic research to study the neurological mechanisms underlying language switching and second language learning using EEG and fMRI. Through these investigations, she aims to advance the understanding of the relationship between human communication cross languages. So far, more than 30 articles have been published as the first author or corresponding author in internationally renowned journals such as NeuroImage, Cerebral Cortex, Human Brain Mapping and Cognition. Meanwhile, some projects have been funded, including National Natural Science Foundation of China Youth Fund, Youth Foundation of Social Science and Humanity, Liaoning Social Science Planning Fund of China, Open Fund of Beijing Key Lab of Applied Experimental Psychology, China Postdoctoral Science Foundation, and Dalian Science and Technology Star Fund of China

Research Interest: 

Bilingual language switching, language learning, EEG, fMRI, TMS, tDCS

Publication list:

1. Linyan Liu, Dongxue Liu, Tingting Guo, John W. Schwieter, & Huanhuan Liu* (2023).The right superior temporal gyrus plays a role in semantic-rule learning: Evidence supporting a reinforcement learning model. NeuroImage, 282, 120393. (SCI-Q1, IF: 5.7, Top).
2. Dongxue Liu, Zehui Xing, Junjun Huang, John W. Schwieter, & Huanhuan Liu* (2023). Genetic bases of language control in bilinguals: evidence from an EEG study. Human Brain Mapping,44(9), 3624-3643. (SCI-Q1, IF: 5.399, Top).
3. Zehui Xing, Tingting Guo, Lanlan Ren, John W. Schwieter, & Huanhuan Liu* (2023). Spatiotemporal evidence uncovers differential neural activity patterns in cognitive and affective conflict control. Behavioural Brain Research, 451,114522. (SCI-Q2, IF: 2.770)
4. Tingting Guo,John W. Schwieter, & Huanhuan Liu* (2023). fMRI reveals overlapping and non-overlapping neural bases of domain-general and emotional conflict control. Psychophysiology,60,e14355.(SSCI/SCI-Q1, IF: 4.348)
5. Shuang Liu, Junjun Huang, John W. Schwieter, & Huanhuan Liu* (2023). The role of morphological configuration in language control during bilingual production and comprehension. Bilingualism: Language and Cognition,26,1067-1078.(SSCI-Q1, IF: 4.763,Top)
6. Huanhuan Liu*, Wenxin Liu,John W. Schwieter, Yanjing Wu. (2023). How processing emotion affects language control in bilinguals. Brain Structure and Function, 228, 635–649. (SCI-Q1, IF: 3.792, Top)
7. Huanhuan Liu*, Zibin Guo,Yishan Jiang, John W. Schwieter, Fenqi Wang (2023). Neural circuits underlying language control and modality control in bilinguals: An fMRI study. Neuropsychologia,178,108430. (SSCI-Q2, IF: 3.054)
8. Dongxue Liu, John W. Schwieter, Wenxin Liug, Li Mu., & Huanhuan Liu*(2023). The COMT gene modulates the relationship between bilingual adaptation in executive function and decision-making: an EEG study. Cognitive Neurodynamics,17,893-907.(SCI-Q2, IF: 5.082)
9. Shuang Liu, John W. Schwieter, Fenqi Wang, & Huanhuan Liu* (2022). An event-related potential study of self-positivity bias in native and foreign language contexts. Psychophysiology, e14145.(SCI-Q1, IF: 4.348)
10. Dongxue Liu, John W. Schwieter, Fenqi Wang, Li Mu., & Huanhuan Liu*(2022). Uncovering the effects of bilingual language control on rational decisions: An ERP study. Psychophysiology, e14066.(SCI-Q1, IF: 4.348)
11. Mingyue Zuo, John W. Schwieter, Ningning Cao, & Huanhuan Liu* (2023). The Role of Language Control in Cross-Language Phoneme Processing: Evidence from Chinese-English Bilinguals. International Journal of Bilingualism, 27(3),293-305.(SSCI-Q1, IF: 1.631)
12. Tingting Guo, Fenqi Wang, Ningning Cao, & Huanhuan Liu*(2022). Conflicts Influence Affects: An fMRI Study of Emotional Effects in a Conflict Task. Cognitive Neurodynamics,16,1261-1271.(SCI-Q2, IF: 5.082)
13. Linyan Liu, John W. Schwieter, Fenqi Wang, & Huanhuan Liu* (2022). First and Second Languages Differentially Affect Rationality When Making Decisions: An ERP Study. Biological Psychology, 108265.(SCI-Q2, IF: 3.251)
14. Huanhuan Liu*,Wanqing Li, Mingyue Zuo, Fenqi Wang, Zibin Guo, & John W. Schwieter. (2022). Cross-Task Adaptation Effects of Bilingual Language Control on Cognitive Control: A Dual-Brain EEG Examination of Simultaneous Production and Comprehension. Cerebral Cortex,32,3224-3242. (SCI-Q1, IF: 5.357, Top)
15. Huanhuan Liu*,Wanqing Li, Angela de Bruinc, & Yuying He. (2021). Should I focus on self-language actions or should I follow others? Cross-language interference effects in voluntary and cued language switching. Acta Psychologica, 216,103308.(SCI-Q3, IF: 1.3)
16. Yuying He, Francesco Margoni, Yanjing Wu, & Huanhuan Liu*. (2021). fMRI Evidence Reveals Emotional Biases in Bilingual Decision Making. Brain Structure and Function, 226:1405-1421. (SCI-Q1, IF: 3.792, Top)
17. Linyan, Liu, Francesco, Margoni, Yuying He, & Huanhuan Liu*. (2021). Neural Substrates of the Interplay between Cognitive Load and Emotional Involvement in Bilingual Decision Making. Neuropsychologia, 151,107721.(SSCI-Q1, IF: 2.872)
18. Huanhuan Liu*, Baike Li, Xin Wang, & Yuying He. (2021). Role of joint language control during cross-language communication: evidence from cross-frequency coupling. Cognitive Neurodynamics, 15, 191–205. (SCI-Q2, IF: 5.082)
19. Huanhuan Liu*, Chao Kong, Angela de Bruin, Junjie Wu, & Yuying He. (2020). Interactive influence of self and other language behaviors: Evidence from switching between bilingual production and comprehension. Human Brain Mapping, 41(13), 3720–3736. (SCI-Q1, IF: 5.399, Top).
20. Huanhuan Liu, Yingying Zhang, Esti Blanco-Elorrieta, Yuying He, & Baoguo Chen*. (2020). The role of proactive control on subcomponents of language control: Evidence from trilinguals. Cognition, 194, 104055. (SSCI-Q1, IF: 3.537, Top).
21. Huanhuan Liu*, Jing Tong, Angela de Bruin, Wanqing Li, Yuying He, & Baike Li. (2020). Is inhibition involved in voluntary language switching? Evidence from transcranial direct current stimulation over the right dorsolateral prefrontal cortex. International Journal of Psychophysiology, 147, 184-192. (SSCI-Q1, IF: 2.631).
22. Jing Tong, Chao Kong, Xin Wang, Huanhuan Liu*, Baike Li, & Yuying He. (2020). Transcranial direct current stimulation influences bilingual language control mechanism: evidence from cross-frequency coupling. Cognitive Neurodynamics, 14, 203-214. (SCI-Q2, IF: 5.082)
23. Man Zhang, Xin Wang, Fenqi Wang, & Huanhuan Liu*. (2020). Effect of Cognitive Style on Language Control During Joint Language Switching: An ERP Study. Journal of Psycholinguistic Research, 49, 383–400. (SSCI-Q3, IF: 0.655)
24. Huanhuan Liu*, Man Zhang, Alejandro Pérez, Ning Xie, Baike Li, & Qiang Liu. (2019). Role of language control during interbrain phase synchronization of cross-language communication. Neuropsychologia, 131, 316-324. (SSCI-Q1, IF: 2.872)
25. Ning Xie, Baike Li, Man Zhang, & Huanhuan Liu*. (2019). Role of top-down language control in bilingual production and comprehension: Evidence from induced oscillations. International Journal of Bilingualism, 23 (5), 1041-1063. (SSCI-Q1, IF: 1.259）
26. Baike Li, Huanhuan Liu*, Pérez, Alejandro, & Ning Xie. (2018). Cathodal transcranial direct current stimulation over right dorsolateral prefrontal cortex improves language control during language switching. Behavioural Brain Research, 351, 34-41. (SCI-Q2, IF: 2.770)
27. Huanhuan Liu, Susan Dunlap, Lijuan Liang, & Baoguo Chen*. (2018). The effect of inhibitory control and its training on L1 and a new learned language switching. International Journal of Bilingualism, 22(6), 653-674. (SSCI-Q1, IF: 1.259)
28. Huanhuan Liu*, Ning Xie, Man Zhang, Xiang Gao, Susan Dunlap, & Baoguo Chen*. (2018). The electrophysiological mechanism of joint language switching: Evidence from simultaneous production and comprehension. Journal of Neurolinguistics, 45, 45-59. (SSCI-Q1, IF: 1.247)
29. Huanhuan Liu, Lijuan Liang, Li Zhang, Yao Lu, & Baoguo Chen*. (2017). Modulatory role of inhibition during language switching: evidence from evoked and induced oscillatory activity. International Journal of Bilingualism, 21(1),57-80. (SSCI-Q1, IF: 1.259)
30. Huanhuan Liu, Susan Dunlap, Yuting Tang, Yao Lu, & Baoguo Chen*. (2017). The modulatory role of L1 and L2 morphosyntactic similarity during production of L2 inflected words: An ERP study. Journal of Neurolinguistics, 42, 109-123. (SSCI-Q1, IF: 1.247)
31. Huanhuan Liu, Susan Dunlap, Michael Shengtao Wu, Lijuan Liang, & Baoguo Chen*. (2017). Inhibitory control predicts quasi language switching performance: evidence from face-to-face dialogue. Language, Cognition and Neuroscience, 32(6), 695-708. (SSCI-Q1, IF: 2.101)
32. Huanhuan Liu, Lijuan Liang, Susan Dunlap, Ning Fan, & Baoguo Chen*. (2016). The effect of domain-general inhibition-related training on language switching: An ERP study. Cognition, 146, 264-276. (SSCI-Q1, IF: 3.537, Top)
33. Huanhuan Liu, Ning Fan, Sonja Rossi, Panpan Yao, & Baoguo Chen*. (2016). The effect of cognitive flexibility on task switching and language switching. International Journal of Bilingualism, 20(5), 563-579. (SSCI-Q1, IF: 1.259)
34. 刘欢欢, & 陈宝国*. (2015). 语言转换的认知及其神经机制.心理科学, 38(1), 98-103. (CSSCI, IF: 1.445)
35. Huanhuan Liu, Sonja Rossi, Huixia Zhou, & Baoguo Chen*. (2014). Electrophysiological evidence for domain-general inhibitory control during bilingual language switching. Plos one, 9(10), e110887. (SSCI-Q1, IF: 3.057)

Research Interest: Use of Neurophysiology to Guide Epilepsy Surgery and the Combined use of Neurophysiology, Functional and Structural Neuroimaging To Study Normal and Abnormal Brain Function and Recovery after Early Brain Injury.B

Research Interest: Intersection between Amyotrophic Lateral Sclerosis and Dementia.

Research Interest: Child Neurologist, Epileptologist and clinical Neurophysiologist

Research Interest:  Pediatrics Neurology Genetics, Neurodevelopmental Disorders.

John F. Bebawy, MD is an Associate Professor of Anesthesiology & Neurological Surgery at Northwestern University.  His clinical and research interests and expertise relate to Neuroanesthesia, with a focus on interventions that affect cerebral blood flow and cerebrovascular hemodynamics.  Dr. Bebawy completed his Anesthesiology residency and Neurosurgical Anesthesiology fellowship training at Northwestern in 2008, where he is currently faculty and Program Director of the Neurosurgical Anesthesiology Fellowship Program.  He is a member of many national and international societies for the advancement of Neurosurgical Anesthesiology, has published widely on various topics in the field, and has spoken at many meetings throughout the world on areas within his expertise.  Dr. Bebawy is devoted and committed to the betterment of patient safety through individualized and compassionate clinical care, as well as through his contribution to the scientific community.

Research Interest:

Neuroanesthesia
Cerebral blood flow
Cerebral physiology
Cerebral pharmacology
Adenosine
Circulatory arrest
Post-craniotomy hypertension
Awake craniotomy
Grant Awards:

Principal Investigator: Aruna Ganju, M.D.

Prot #CL-SCI-201: A Single-Blind, Randomized, Parallel Arm, Phase II Proof-of-Concept
Study of the Safety and Efficacy of HuCNS-SC Transplantation in Cervical Spinal Cord Injury

      6/17/2015 - 5/31/2016

      Document ID: Prot #CL-SCI-201

      Sponsor: PRA Health Sciences

      Role: Co-Investigator

Publications:

1.   Bebawy JF, Gupta DK, Cotton MA, Gil KS, Fohrman EB, Mirkovic S, Koht A. Alternative anterior reference sites for measuring posterior tibial nerve somatosensory evoked potentials. J Clin Monit Comput. 2010;24(2):107-11. PMID: 20063048.

2.    Bebawy JF, Gupta DK, Bendok BR, Hemmer LB, Zeeni C, Avram MJ, Batjer HH, Koht A. Adenosine-induced flow arrest to facilitate intracranial aneurysm clip ligation: dose-response data and safety profile. Anesth Analg. 2010;110(5):1406-11. PMID: 20418302.

3.    Lin N, Bebawy JF, Hua L, Wang B. Is L2-L3 interspace spinal anaesthesia safe in disorders of the vertebral column? A magnetic resonance imaging study. Br J Anaesth. 2010;105(6):857-62. PMID: 20846965.

4.    Bendok BR, Gupta DK, Rahme RJ, Eddleman CS, Adel JG, Sherma AK, Surdell DL, Bebawy JF, Koht A, Batjer HH. Adenosine for temporary flow arrest during intracranial aneurysm surgery: a single center retrospective review. Neurosurgery. 2011;69(4):815-21. PMID: 21637138.
5.    Bebawy JF, Ramaiah VK, Zeeni C, Hemmer LB, Koht A, Gupta DK. The effect of furosemide on intravascular volume status and electrolytes in patients receiving mannitol: an intraoperative safety analysis. J Neurosurg Anesthesiol. 2013;25(1):51-4. PMID: 23237936.

6.    Bebawy JF, Zeeni C, Sharma S, Kim ES, DeWood MS, Hemmer LB, Ramaiah VK, Bendok BR, Koht A, Gupta DK. Adenosine-induced flow arrest to facilitate intracranial aneurysm clip ligation does not worsen neurologic outcome. Anesth Analg. 2013;117(5):1205-10. PMID: 24108260.

7.    Sharma D, Bilotta F, Moore LE, Bebawy JF, Flexman AM, Rochlen L, Gorji R, Avitsian R. Web-based educational activities developed by the Society for Neuroscience in Anesthesiology and Critical Care (SNACC): the experience of process, utilization, and expert evaluation. J Neurosurg Anesthesiol. 2014;26(1):4-10. PMID: 23792804.

8.    Hemmer LB, Zeeni C, Bebawy JF, Bendok BR, Cotton MA, Shah NB, Gupta DK, Koht A. The incidence of unacceptable movement with motor evoked potentials during craniotomy for aneurysm clipping. World Neurosurg. 2014;81(1):99-104. PMID: 23043993.

9.    Carabini LM, Zeeni C, Moreland NC, Gould RW, Avram MJ, Hemmer LB, Bebawy JF, Sugrue PA, Koski TR, Koht A, Gupta DK. Development and validation of a generalizable model for predicting major transfusion during spine fusion surgery. J Neurosurg Anesthesiol. 2014;26(3):205-15. PMID: 24714381.

10.    Carabini LM, Zeeni C, Moreland NC, Gould RW, Hemmer LB, Bebawy JF, Koski TR, McClendon J, Koht A, Gupta DK. Predicting major adverse cardiac events in spine fusion patients: is the Revised Cardiac Risk Index sufficient? Spine (Phila Pa 1976). 2014;39(17):1441-8. PMID: 24825150.

11.    Zeeni C, Carabini LM, Gould RW, Bebawy JF, Hemmer LB, Moreland NC, Koski TR, Koht A, Schafer MF, Ondra SL, Gupta DK. The implementation and efficacy of the Northwestern High Risk Spine Protocol. World Neurosurg. 2014;82(6):e815-23. PMID: 24947117.

*Accompanying editorial: Bydon M, Gokaslan ZL. A novel protocol for reducing perioperative morbidity in complex spinal fusion surgery. World Neurosurg. 2014;82(6):e715-6. PMID:  25153297.

12.    Carabini LM, Navarre WJ, Ault ML, Bebawy JF, Gupta DK. A comparison of hemoglobin measured by co-oximetry and central laboratory during major spine fusion surgery. Anesth Analg. 2015;120(1):60-5. PMID: 25185592.

*Accompanying editorial: Morey TE, Rice MJ, Gravenstein N. What is a reference standard? Anesth Analg. 2015;120(1):8-9. PMID: 25625249.

13.    Bebawy JF, Houston CC, Kosky JL, Badri AM, Hemmer LB, Moreland NC, Carabini LM, Koht A, Gupta DK. Nicardipine is superior to esmolol for the management of post-craniotomy emergence hypertension: a randomized open-label study. Anesth Analg. 2015;120(1):186-92. PMID: 25296247.

14.    Lin N, Li Y, Bebawy JF, Dong J, Hua L. Abdominal circumference but not the degree of lumbar flexion affects the accuracy of lumbar interspace identification by Tuffier’s line palpation method: an observational study. BMC Anesthesiol. 2015;15(1):9. PMID: 25670920.

15.    Errando CL, Garutti I, Mazzinari G, Diaz-Cambronero O, Bebawy JF; Grupo Español de Estudio del Bloqueo Neuromuscular. Residual neuromuscular blockade in the postanesthesia care unit. Observational cross-sectional study of a multicenter cohort. Minerva Anestesiol. 2016;82(12):1267-77. PMID: 27232277.

16.    Yee JN, Koht A, McCarthy RJ, Bebawy JF. Factors associated with blood transfusion during intracranial aneurysm surgery. J Clin Anesth. 2017;36:164-7. PMID: 28183559.

17.    Carabini LM, Moreland NC, Vealey RJ, Bebawy JF, Koski TR, Koht A, Gupta DK, Avram MJ; Northwestern High Risk Spine Group. A randomized controlled trial of low dose tranexamic acid versus placebo to reduce red blood cell transfusion during complex multilevel spine fusion surgery. World Neurosurg. 2018;110:e572-9. PMID: 29175569.
b.    Reviews, Case Reports, Letters, Editorials
1.    Bebawy JF, Koht A. Review: Cottrell and Young’s Neuroanesthesia, 5th ed. Anesth Analg. 2011;112(2):488-9.

2.    Bebawy JF, Gupta DK, Koht A. Compartment syndrome caused by a properly functioning infusion pump. J Clin Anesth. 2011;23(2):134-6. PMID: 21377078.

3.    Bebawy JF. Rocuronium bromide. Anesthesiology. 2011;114(6):1486. PMID: 21263302.

4.    Bebawy JF. State of the art. Anesthesiology. 2011;114(6):1487. PMID: 21399491.
5.    Rahme RJ, Adel JG, Bendok BR, Bebawy JF, Gupta DK, Batjer HH. Association of intracranial aneurysm and Loeys-Dietz Syndrome: case illustration, management, and literature review. Neurosurgery. 2011;69(2):488-93. PMID: 21792144.

6.    Bebawy JF, Ramaiah VK, Hemmer LB, Gupta DK. Clinical pharmacology of insulin confounds stroke trials. Ann Neurol. 2012;71(1):148-9. PMID: 21425188.

7.    Bebawy JF. Perioperative steroids for peritumoral intracranial edema: a review of mechanisms, efficacy, and side effects. J Neurosurg Anesthesiol. 2012;24(3):173-7. PMID: 22544067.

8.    Bendok BR, El Tecle N, El Ahmadieh TY, Bebawy JF, Gupta DK, Hemmer LB, Koht A. Comment on: Surgical treatment of 127 anterior choroidal artery aneurysms: a cohort study of resultant ischemic complications. Neurosurgery. 2013;73(6):939-40. PMID: 23921702.

9.    Bebawy JF, Bilotta F, Koht A. A modified technique for auriculotemporal nerve blockade when performing selective scalp nerve block for craniotomy. J Neurosurg Anesthesiol. 2014;26(3):271-2. PMID: 24492515.

10.    Bebawy JF, Gupta DK. In response. Anesth Analg. 2015;121(5):1399-400. PMID: 26484469.

11.    Lewis C, Parulkar SD, Bebawy J, Sherwani S, Hogue CW. Cerebral neuromonitoring during cardiac surgery: a critical appraisal with an emphasis on near-infrared spectroscopy. J Cardiothorac Vasc Anesth. 2018;32(5):2313-22. PMID: 30100271.
c.    Books and Book Chapters
1.    Zeeni C, Bebawy JF, Gupta DK, Koht A. Anesthesia considerations for neurovascular surgery. In: Bendok BR, Batjer HH, Naidech AM, Walker MT, eds. Hemorrhagic and Ischemic Stroke: Medical, Imaging, Surgical, and Interventional Approaches. 1st ed. New York, NY: Thieme; 2012:171-81.

2.    Bebawy JF, Koht A, Mirkovic S. Anterior cervical spine surgery. In: Koht A, Sloan TB, Toleikis JR, eds. Monitoring the Nervous System for Anesthesiologists and Other Health Care Professionals. 1st ed. New York, NY: Springer; 2012:539-54.

3.    Bebawy JF, Koht A. Autonomic hyperreflexia. In: Singh-Radcliff N, ed. The 5-Minute Anesthesia Consult. 1st ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2013:110-1.

4.    Bebawy JF, Koht A. Anesthesia for neurosurgery. In: Barash PG, Cullen BF, Stoelting RK, Cahalan MK, Stock MC, Ortega RA, Sharar SR, eds. Clinical Anesthesia Fundamentals. 1st ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2015:557-76.

5.    Bebawy JF, Pasternak JJ. Anesthesia for neurosurgery. In: Barash PG, Cullen BF, Stoelting RK, Cahalan MK, Stock MC, Ortega RA, Sharar SR, Holt NF, eds. Clinical Anesthesia. 8th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2017:1003-28.
6.    Bebawy JF, Koht A, Mirkovic S. Anterior cervical spine surgery. In: Koht A, Sloan TB, Toleikis JR, eds. Monitoring the Nervous System for Anesthesiologists and Other Health Care Professionals. 2nd ed. New York, NY: Springer; 2017:473-83.
    d.   Software, world wide web-based publications, exhibits, audiovisual or other teaching     material
1.    Bebawy JF. SNACC Blog: Traumatic spinal cord injury. http://snacc.org/blog.php. Updated March 1, 2011.

2.    Bebawy JF. Page 2 Anesthesiology Blog: John F. Bebawy answers some questions about his Mind-to-Mind poems. http://page2anesthesiology.org/?p=1157. Updated June 1, 2011.

3.    Bebawy JF. ICE-TAP Module 8: Evoked potentials. http://www.icetap.org/modules/evoked_potentials.html. Updated March 14, 2012.

4.    Gelb AW, Bebawy JF. SNACC Chat with the Author: The role of hypotension in perioperative stroke. http://snacc.org/members/gelb-chat.iphtml. Updated May 9, 2013.

5.    Bebawy JF. SNACC 2013 Teacher of the Year Award: Antoun Koht, M.D. http://snacc.org/educatoraward.iphtml. Updated December 12, 2013.

6.    Bebawy JF, Brambrink AM. SNACC Article of the Month (April 2014): Developmental effects of neonatal isoflurane and sevoflurane exposure in rats, Seubert et al. http://snacc.org/members/articles/aotm_apr2014.pdf. Updated April 2, 2014.

7.    Bebawy JF, Lee CZ, Gelb AW. SNACC Article of the Month (May 2014): Society for Neuroscience in Anesthesiology and Critical Care expert consensus statement: anesthetic management of endovascular treatment for acute ischemic stroke: endorsed by the Society of NeuroInterventional Surgery and the Neurocritical Care Society, Talke et al. http://snacc.org/members/articles/aotm_may2014.pdf. Updated April 30, 2014.


8.    Bebawy JF, Heyer EJ, Anastasian ZH. SNACC Article of the Month (June 2014): Monitoring depth of anesthesia utilizing a combination of electroencephalographic and standard measures, Schneider et al. http://snacc.org/members/articles/aotm_june2014.pdf. Updated June 2, 2014.

9.    Bebawy JF, Koht A. ASNM “The Monitor” Educational Note: Anesthesia (July 2014): Pitfalls and predicaments in anesthesia for cases requiring neurophysiological
monitoring. http://asnm.site-ym.com/resource/resmgr/The_Monitor/July_2014.pdf. Updated July 1, 2014.

10.    Bebawy JF, Lam AM. SNACC Article of the Month (July 2014): A decrease in spatially resolved near-infrared spectroscopy-determined frontal lobe tissue oxygenation by phenylephrine reflects reduced skin blood flow, Ogoh et al. http://snacc.org/members/articles/aotm_july2014.pdf. Updated July 2, 2014.

11.    Bebawy JF, Koht A. ASNM “The Monitor” Educational Note: Anesthesia (August 2014): Monitoring muscle relaxant activity during IOM. http://asnm.site-ym.com/resource/resmgr/The_Monitor/August_2014.pdf. Updated August 1, 2014.

12.    Bebawy JF, Tate MC. SNACC Article of the Month (August 2014): The impact of sedation on brain mapping: a prospective, interdisciplinary, clinical trial, Ott et al. http://snacc.org/members/articles/aotm_august2014.pdf. Updated August 1, 2014.

13.    Bebawy JF, Bilotta F. SNACC Article of the Month (September 2014): Incidence of postoperative cognitive dysfunction after general or spinal anesthesia for extracorporeal shock wave lithotripsy, Silbert et al. http://snacc.org/members/articles/aotm_sept2014.pdf. Updated September 2, 2014.

14.    Bebawy JF, Roginski RS. SNACC Article of the Month (October 2014): Ischemic stroke injury is mediated by aberrant Cdk5, Meyer et al. http://snacc.org/members/articles/aotm_oct2014.pdf. Updated October 1, 2014.

15.    Bebawy JF, Moore LE. SNACC Article of the Month (November 2014): Time elapsed after ischemic stroke and risk of adverse cardiovascular events and mortality following elective noncardiac surgery, Jorgensen et al. http://snacc.org/members/articles/aotm_nov2014.pdf. Updated October 29, 2014.



16.    Bebawy JF, Maktabi MA. SNACC Article of the Month (December 2014): Intubation biomechanics: laryngoscope force and cervical spine motion during intubation with Macintosh and Airtraq laryngoscopes, Hindman et al. http://snacc.org/aotm/aotm_dec2014.pdf. Updated December 1, 2014.

17.    Bebawy JF, Edelman G. SNACC Article of the Month (January 2015): Long-term outcomes after stenting versus endarterectomy for treatment of symptomatic carotid stenosis: the International Carotid Stenting Study (ICSS) randomised trial, Bonati et al. http://snacc.org/aotm/aotm_jan2015.pdf. Updated December 31, 2014.

18.    Bebawy JF, Sharma D. SNACC Article of the Month (February 2015): Shoulder surgery in the beach chair position is associated with diminished cerebral autoregulation but no differences in postoperative cognition or brain injury biomarker levels compared with supine positioning: the Anesthesia Patient Safety Foundation Beach Chair Study, Laflam et al. http://snacc.org/aotm/aotm_feb2015.pdf. Updated February 5, 2015.

19.    Bebawy JF, Sloan TB. SNACC Article of the Month (March 2015): Transcranial motor evoked potentials during anesthesia with desflurane versus propofol - a prospective randomized trial, Malcharek et al. http://snacc.org/aotm/aotm_mar2015.pdf. Updated March 3, 2015.

20.    Bebawy JF, Armstead WM. SNACC Article of the Month (April 2015): Differing effects when using phenylephrine and norepinephrine to augment cerebral blood flow after traumatic brain injury in the immature brain, Friess et al. http://www.snacc.org/wp-content/uploads/2015/04/SNACC-April-Article-of-The-Month.pdf. Updated April 1, 2015.

21.    Bebawy JF, Vavilala MS. SNACC Article of the Month (May 2015): Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system, Plog et al. http://www.snacc.org/wp-content/uploads/2015/05/SNACC_May_2015_Article_of_The_Month.pdf. Updated May 1, 2015.

22.    Bebawy JF, Blair JL, Lee LA. SNACC Article of the Month (June 2015): Effect of perioperative intravenous lidocaine administration on pain, opioid consumption, and quality of life after complex spine surgery, Farag et al. http://www.snacc.org/wp-content/uploads/2015/06/SNACC-Article-of-The-Month-June-2015.pdf. Updated June 9, 2015.


23.    Bebawy JF, Ramani R. SNACC Article of the Month (July 2015): Successful serial imaging of the mouse cerebral arteries using conventional 3-T magnetic resonance imaging, Makino et al. http://www.snacc.org/wp-content/uploads/2015/07/SNACC-Article-of-the-Month-July-2015.pdf. Updated July 1, 2015.

24.    Bebawy JF, Kofke WA. SNACC Article of the Month (August 2015): The monitoring and management of severe traumatic brain injury in the United Kingdom: is there a consensus?: a national survey, Wijayatilake et al. http://www.snacc.org/wp-content/uploads/2015/08/SNACC_Article_of_The_Month_August2015.pdf. Updated August 4, 2015.

25.    Bebawy JF, Zaslavsky A, Bekker AY. SNACC Article of the Month (September 2015): The opioid-sparing effect of intraoperative dexmedetomidine infusion after craniotomy, Song et al. http://www.snacc.org/wp-content/uploads/2015/09/SNACC-September-2015-AOTM.pdf. Updated September 1, 2015.

26.    Bebawy JF, Kositratna G. SNACC Article of the Month (October 2015): Up-regulation of Cathepsin G in the development of chronic postsurgical pain: an experimental and clinical genetic study, Liu et al. http://www.snacc.org/wp-content/uploads/2015/10/SNACC-October-Article-of-The-Month.pdf. Updated October 2, 2015.

27.    Bebawy JF. F1000 Prime Published Recommendation: Anesthetic management of patients undergoing intracranial bypass procedures, Chui et al. http://f1000.com/prime/contributor/evaluate/article/725734291. Updated November 26, 2015.

28.    Bebawy JF, Kreilinger SE. SNACC Article of the Month (December 2015): Hypothermia for intracranial hypertension after traumatic brain injury, Andrews et al. http://www.snacc.org/wp-content/uploads/2015/12/SNACC_December_AOTM.pdf. Updated December 10, 2015.

29.    Bebawy JF, Kositratna G, Wyler D. SNACC Article of the Month (January 2016): MicroRNA-200c contributes to injury from transient focal cerebral ischemia by targeting Reelin, Stary et al. http://www.snacc.org/wp-content/uploads/2016/01/SNACC-1-2016-Article-of-The-Month.pdf. Updated January 6, 2016.

30.    Bebawy JF, Lele A. SNACC Article of the Month (February 2016): Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): a randomised controlled trial, Bernhardt et al. http://www.snacc.org/wp-content/uploads/2016/01/SNACC-Article-of-The-Month_2-2016.pdf. Updated January 30, 2016.
31.    Bebawy JF, Souter MJ. SNACC Article of the Month (March 2016): Variability of brain death policies in the United States, Greer et al. http://www.snacc.org/wp-content/uploads/2016/03/SNACC-Article-of-The-Month_3-2016.pdf. Updated March 10, 2016.

32.    Maties O, Bebawy JF, Hetts SW. SNACC Article of the Month (April 2016): The durability of endovascular coiling versus neurosurgical clipping of ruptured cerebral aneurysms: 18 year follow-up of the UK cohort of the International Subarachnoid Aneurysm Trial (ISAT), Molyneux et al. http://www.snacc.org/wp-content/uploads/2016/04/SNACC-Article-of-The-Month_4-2016.pdf. Updated April 4, 2016.

33.    Bebawy JF, Maties O, Sall JW. SNACC Article of the Month (May 2016): Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial, Davidson et al. http://www.snacc.org/wp-content/uploads/2016/05/SNACC-Article-of-the-Month-May-2016.pdf. Updated May 12, 2016.

34.    Bebawy JF. F1000 Prime Published Recommendation: Dexmedetomidine does not affect evoked potentials during spine surgery, Rozet et al. http://f1000.com/prime/contributor/evaluate/article/725579743. Updated May 20, 2016.

35.    Maties O, Bebawy JF, Moore LE. SNACC Article of the Month (June 2016): Mild sedation exacerbates or unmasks focal neurologic dysfunction in neurosurgical patients with supratentorial brain mass lesions in a drug-specific manner, Lin et al. http://www.snacc.org/wp-content/uploads/2016/06/AOTM_June_2016.pdf. Updated June 1, 2016.

36.    Maties O, Bebawy JF, Deiner SG. SNACC Article of the Month (August 2016): Preoperative cognitive stratification of older elective surgical patients: a cross-sectional study, Culley et al. http://www.snacc.org/wp-content/uploads/2016/08/SNACC-Article-of-The-Month_8-2016.pdf. Updated August 5, 2016.

37.    Bebawy JF, Maties O, Manninen PH. SNACC Article of the Month (September 2016): Awake craniotomy to maximize glioma resection: methods and technical nuances over a 27-year period, Hervey-Jumper et al. http://www.snacc.org/wp-content/uploads/2016/09/SNACC-Article-of-The-Month_9-2016.pdf. Updated September 1, 2016.


38.    Maties O, Bebawy JF, Lieberman JA. SNACC Article of the Month (October 2016): Reversible intraoperative neurophysiologic monitoring alerts in patients undergoing arthrodesis for adolescent idiopathic scoliosis: what are the outcomes of surgery?, Samdani et al. http://www.snacc.org/wp-content/uploads/2016/10/SNACC-Article-of-The-Month_10-2016.pdf. Updated October 7, 2016.

39.    Bebawy JF. F1000 Prime Published Recommendation: The effects of dexmedetomidine and remifentanil on hemodynamic stability and analgesic requirement after craniotomy: a randomized controlled trial, Rajan et al. http://f1000.com/prime/contributor/evaluate/article/725760816. Updated October 10, 2016.

40.    Bebawy JF. SNACC Winter 2016 Newsletter: Update from the SNACC Education Committee. http://www.snacc.org/wp-content/uploads/2016/12/SNACC-WInter-Newsletter2016-PUB.pdf. Updated December 16, 2016.

41.    Bebawy JF. F1000 Prime Published Recommendation: The intraoperative effect of methadone on somatosensory evoked potentials, Higgs et al. https://f1000.com/prime/726015339. Updated April 19, 2017.

42.    Bebawy JF. F1000 Prime Published Recommendation: Transcranial motor-evoked potentials are more readily acquired than somatosensory-evoked potentials in children younger than 6 years, McIntyre et al. https://f1000.com/prime/725891191. Updated July 31, 2017.

43.    Bebawy JF. F1000 Prime Published Recommendation: Intravenous acetaminophen does not reduce inpatient opioid prescription or opioid-related adverse events among patients undergoing spine surgery, Mörwald et al. https://f1000.com/prime/732925326. Updated May 2, 2018.

d.    Abstracts (past 2 years)
1.    Moreland NC, Carabini LM, Vealey RJ, Bebawy JF, Avram MJ. The use of low dose tranexamic acid to reduce red blood cell transfusion during complex multilevel spine fusion. Society for Neuroscience in Anesthesiology and Critical Care, Chicago, Illinois, October 2016.

2.    Moreland NC, Carabini LM, Vealey RJ, Bebawy JF, Koht A, Avram MJ. The use of low dose tranexamic acid to reduce red blood cell transfusion during complex multilevel spine fusion. Journal Symposium: Coagulation 2016: New Drugs and New Data, American Society of Anesthesiologists, Chicago, Illinois, October 2016.

3.    George AS, Koht A, Bebawy JF. Anesthesia in a patient with abdominal aortic aneurysm and cervical stenosis undergoing suboccipital craniotomy: not too high, not too low, but just right! Society for Neuroscience in Anesthesiology and Critical Care, Boston, Massachusetts, October 2017.

4.    Hull CR, Bebawy JF. Differential diagnosis of delayed emergence in a patient with septic shock. Midwest Anesthesia Residents Conference, Cincinnati, Ohio, April 2018.

5.    George A, Koht A, Bebawy J. Unilateral, lower extremity loss of somatosensory evoked potential in a patient undergoing general anesthesia for spine surgery. Society for Neuroscience in Anesthesiology and Critical Care, San Francisco, California, October 2018.

6.    Ford K, Uejima J, Moreland N, Zeeni C, Hemmer L, Bebawy J, Koht A, McCarthy R, Carabini L. A retrospective study comparing discrepancy between estimated and calculated blood loss and infectious complications in multilevel spinal fusion surgery. Society for Neuroscience in Anesthesiology and Critical Care, San Francisco, California, October 2018.

Research Interest: Cobalamin, Central Nervous System, Cytokines, Growth Factors, Normal prion and Myelin.

Research Interest: Research Interests Include The Role Of The Brain In Mediating High Blood Pressure Including Neurogenic, Chronic Stress Induced And Obesity Related Hypertension

Research Interest:Neurology Chinese Medicine, Neurosology, Cognitive Disorders, Movement Disorders
Neurophysiology.

Research Interest:  Disorders of consciousness, Coma, Brain death, Clinical Neurophysiology

Autonomic Nervous System Stroke, Neuromonitoring, Autism.

Research Interest: Adult Nurogenesis and Cognition

Dr. Zhi Dong Zhou is graduated as a medical doctor in 1991 and had 5 years of postgraduate clinical training in internal medicine in China. Subsequently he acquired my Ph.D from Chinese Academy of Science, Shanghai Branch and started me research career in Singapore on dopamine (DA) neuron degeneration in Parkinson's disease (PD). Later he joined the National Neuroscience Institute (NNI) as a member of the Singapore National PD Translational Bench to Bedside team and continue to work on DA neuron degeneration in PD. Currently, he is an Associate Clinician Scientist in charge of the Translational Therapeutics Laboratory of NNI and an Assistant Professor at Duke-NUS, NBD as well as a PI of NMRC and SHF grants.

Research Interest: Dr. Zhi Dong Zhou’s interests lie in identification and verification of novel key molecular targets, signaling pathways or neuro-protective agents relevant to pathogenesis and therapy of debilitating human neurodegenerative diseases, including PD, Alzheimer’s disease (AD) and multiple sclerosis.

Publications:

1). Zhi Dong Zhou & Eng King Tan. Dopamine (DA) toxicity in pathogenesis and therapy of Parkinson’s disease (PD). J Clin Bioanal Chem 2017 Volume 1 Issue 1, in press.
2). Zhi Dong Zhou & Eng King Tan. Iron Regulatory Protein (IRP)-Iron Responsive Element (IRE) Signaling Pathway in Human Neurodegenerative Diseases. Molecular Neurodegeneration, in press
3). Zhong Can Zhen., ..Zhi Dong Zhou, et al. LRRK2 Interacts with ATM and Regulates Mdm2-p53 Cell Proliferation Axis in Response to Genotoxic Stress. Human Molecular Genetics. In press.
4). Bin Xiao, Xiao Deng, Grace Lim, Shaoping Xie, Zhi Dong Zhou, and et al. Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria. Cell death and Disease. 2017. in press
5). Zhong Can Chen,,, Zhi Dong Zhou, et al. Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson’s disease. Science Signaling. 2017. in press
6). Lifeng Qiu, Mei-Chih Liao, Allen K Chen,, Zhi Dong Zhou, et al. Immature midbrain dopaminergic neurons derived from floor-plate method improve cell transplantation therapy efficacy for Parkinson’s disease. STEM CELLS Translational Medicine, in press.
7). Bin Xiao;, Zhi Dong Zhou; et al. p62-Mediated Mitochondrial Clustering Attenuates Apoptosis Induced by Mitochondrial Depolarization. BBA - Molecular Cell Research, 2017; 1864(7):1308-1317.
8). Murni T, Wen RJ, ,Zhi Dong Zhou, et al. Varied pathological and therapeutic response effects associated with CHCHD2 mutant and risk variants. Human mutation, 2017 Apr 21, doi: 10.1002/humu.23234.
9). Zhi Dong Zhou, Chao YX, Tan EK. Potential Implications of Mitochondrial Unfolded Protein Response in the Pathogenesis and Therapy of Dopaminergic Neuron Degeneration in Parkinson’s Disease. JSM Biotechnol Bioeng 2017; 4(1): 1075.
10), Zhi Dong Zhou* et al. Dopamine (DA) Dependent Toxicity Relevant to DA Neuron Degeneration in Parkinson’s Disease (PD). Austin Journal Of Drug Abuse And Addiction. 2016; 3(1): 1010. Corresponding author.....